ABSTRACT
This study determines the expression of latent membrane protein-1 [LMP- 1] in lymph nodes of patients with classic Hodgkin lymphoma [cHL] and its role in patients' survival. Specimen of 98 patients who had cHL was chosen and the samples were immunohistochemically stained with LMP-1 and Overall disease-free survival [DFS] was measured from the date of complete remission until the Relapse was confirmed by another lymph node biopsy. We investigated the expression of LMP-1 in outcome of patients with cHL. LMP-1 was detected in RS cells of cHL in twenty five out of ninety eight [25.5%] patients. LMP-1 expression was significantly more frequent in mixed cellularity, 46.7%, than nodular sclerosis, 15.4% [P= 0.005]. Patients with EBV-positive tumors had fewer DFS [22.6 vs. 25.9 mo], but the difference was not statistically significant [p=0.06]. Although in our study there is no relationship between age and LMP-1 expression. LMP-1 expression is associated with statistically different DFS in treated patients with cHL
Subject(s)
Humans , Male , Female , Hodgkin Disease/analysis , Viral Matrix Proteins/analysis , Viral Matrix Proteins , Lymph Nodes/analysis , Epstein-Barr Virus Infections/diagnosis , Epstein-Barr Virus Infections/complications , Immunohistochemistry/statistics & numerical data , Disease-Free Survival , Cross-Sectional Studies , Survival AnalysisABSTRACT
Para conocer la utilidad de la impronta de ganglio linfático, se revisó el archivo de citomorfología del laboratorio de Estudios Espaciales del Servicio de Hematología en el período de febrero de 1983 a diciembre de 1986 y se correlacionó con los reportes de histopatología de la Unidad de Patolog del Hospital General, S.S. Se revisaron 44 improntas de pacientes con diagnóstico en 31 casos (72%) y no habiendo correlación diagnóstico en 13 casos (28%). Los resultados de este estudio justifican la introducción de la impronta de ganglio dentro de los exámenes de procedimientos diagnóstico en pacientes con probable linfoma. Su uso sicesivo y la adquisición de mayor experiencia del observador hará que este porcentaje se mejore sin que reemplace el diagnóstico histopatológico .
Subject(s)
History, 20th Century , Clinical Laboratory Techniques , Lymphoma/diagnosis , Lymph Nodes/analysis , Lymph Nodes/cytology , MexicoABSTRACT
Os autores, analisam a sobrevida de 452 pacientes portadores de adenocarcinoma gástrico matriculados no Departamento de Cirurgia Abdominal do Hospital A.C. Camargo e operados com finalidade radical. Os resultados säo apresentados de acordo com o estádio clínico e o número de linfonodos contaminados, verificando-se que os resultados declinam do EC I para o EC III e também com o número de linfonodos contaminados. Fazem também estudo comparativo dos resultados de tratamento em dois períodos: 1953 e 1970-1980, demonstrando melhora nos índices de sobrevida no segundo período